Method 48 rats were given the opportunity to self administer at one of four low nicotine doses 15 7.5 3.75 0.0 µg/kg/infusion before and after self administering a higher dose of nicotine 60 µg/kg/infusion . A second group of 57 rats acquired self administration at the high nicotine dose before experiencing reduction.
Methods In nicotine and amphetamine self administration and sucrose maintained responding experiments rats responded for nicotine 0.01 or 0.02 mg/kg per infusion IV amphetamine 0.2 mg/kg per infusion IV and sucrose pellets 45 mg respectively on a fixed ratio 5 schedule.
Dec 01 1995 Male Sprague Dawley rats trained on food reinforcement acquired relatively high and stable rates of self administration of IV nicotine bitartrate 0.03 mg/kg free base . Extinction and reacquisition followed substituting saline and then nicotine respectively.
Jun 16 2020 Self administration of the 0.5 mg/ml nicotine dose led to blood nicotine levels that were very similar to human smokers and rats that self administer nicotine intravenously at the optimal dose of
In this procedure rats are trained to self administer a drug of abuse e.g. nicotine cocaine by lever pressing in an operant box. Once rats exhibit stable drug intake the training drug is substituted with a testing compound. If the testing compound is self administered this indicates potential drug abuse liability.
The reinforcing effect of nicotine was investigated using the intravenous self administration method in rats. After forced iv injection of nicotine 3 10 and 30 micrograms/kg/inj at 1 hr intervals for 3 days in 3 dose level groups self administration sessions under the continuous reinforcement schedule were carried out for 15 days.
Nicotine and cocaine self administration using a multiple schedule of intravenous drug and sucrose reinforcement in rats Nicotine and neurodegeneration in ageing Nicotine and familial vulnerability to schizophrenia a discordant twin study Nicotine and ethanol interact during adolescence effects on the central cholinergic systems
May 01 2010 Rationale Nicotine intravenous self administration IVSA in rats has been conducted using a variety of methodological procedures with equally variable results. Objectives Here we addressed the importance of the type of response operandum and prior instrumental training with a natural reinforcer on nicotine IVSA and reinstatement. Methods Rats were
The reinforcing properties of a variety of drugs abused by humans have been investigated using the technique of intravenous self administration in the rat. To examine the effect of nicotine dose on nicotine self administration Wistar rats were allowed to self administer various doses of nicotine using a within subjects Latin square design.
Effects of nornicotine enantiomers on intravenous S − nicotine self administration and cardiovascular function in rats. Psychopharmacology 2007. Nichole Neugebauer. Effect of a novel nicotinic receptor antagonist N N′ dodecane 1 12 diyl bis 3 picolinium dibromide on nicotine self administration and hyperactivity in rats.
Dec 02 2010 This study demonstrated that rats will reliably self administer nicotine via an IV route by making a licking response. The operant licking response increased with continued experience with licking causing the delivery of nicotine.
Oct 01 2010 Read Patterns of responding differentiate intravenous nicotine self administration from responding for a visual stimulus in C57BL/6J mice Psychopharmacology on DeepDyve the largest online rental service for scholarly research with thousands of academic publications available at your fingertips.
Nicotine and cocaine self administration using a multiple schedule of intravenous drug and sucrose reinforcement in rats. Share this page Title Nicotine and cocaine self administration using a multiple schedule of intravenous drug and sucrose reinforcement in rats. Publication Type Journal Article Google Scholar
Intravenous nicotine maintained substantial responding on the drug reinforced lever with a limited access fixed ratio 5 schedule of self administration. Responding demonstrated the expected pharmacological sensitivity it was dose dependently reduced by pre session treatment with either nicotine or mecamylamine but not with hexamethonium. In addition responding
The present study examined instead the impact of a motivationally neutral cue on self administration. Methods Adult male Long Evans rats were permitted to self administer nicotine 0.015 mg/kg IV given over 30 s 2 h/day or saline presented with or without a sensory stimulus light white noise .
Dec 16 2014 In this study we report the effect of orally delivered menthol as a cue for the intravenous self administration IVSA of nicotine in adolescent rats using licking as the operant response Levin et al. 2010 Chen et al. 2011 . We first compared the effects of menthol and vehicle cues on nicotine self administration.
chronic nicotine exposure George et al. 2010 Gilpin et al. 2014 and escalation of intravenous nicotine self administration in nicotine vapor exposed rats Gilpin et al. 2014 . However this approach also does not use the same liquid solution or electronic and heat elements that are contained in e cigarettes used by humans.
Aug 01 2006 The self administration of intravenous nicotine 0.015–0.060 mg/kg per infusion in P rats was more than twice than that of NP rats. Nicotine seeking induced by reexposure to nicotine cues in extinction tests was also substantially greater in P
In nicotine and amphetamine self administration and sucrose maintained responding experiments rats responded for nicotine 0.01 or 0.02
20 nicotine rats pressed for an average of 9 rewards per hour resulting in blood nicotine levels of 62 ng/ml Fig. 1B . The current gold standard animal model of nicotine use is intravenous self administration 18 19 . Therefore we confirmed that our nicotine vapor model produced similar blood nicotine levels as the intravenous model Fig
In the current study rats were trained to self administer intravenous nicotine 0.03 mg/kg/infusion for 21 days in 1 hour daily sessions with an incrementing fixed ratio requirement a control group received saline infusions.
Rationale Nicotine intravenous self administration IVSA in rats has been conducted using a variety of methodological procedures with equally variable results. Objectives Here we addressed the importance of the type of response operandum and prior instrumental training with a natural reinforcer on nicotine IVSA and reinstatement.
Feb 05 2020 Nicotine self administration The apparatus and detailed procedures for both intravenous catheterization and nicotine self administration have been described previously.17 The rats were first trained to nosepoke for food and water in 23 h sessions before and after recovery from the surgical implantation of
Methods Rats were classified as sign or goal trackers during a Pavlovian conditioned approach paradigm. Rats then self administered intravenous nicotine 0.03 mg/kg infusions followed by extinction and cue induced reinstatement tests. We also
IV nicotine self administration in rats using a consummatory operant licking response Sensitivity to serotonergic glutaminergic and histaminergic drugs By Vanessa Cousins Jed E. Rose and Edward D. Levin
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